• Test Code:
  • Department:
    Molecular Genetics
  • Test Synonyms:
    Syncopal Episodes • Torsades de pointes tachyarrythmia • Atrial Fibrillation • Ventricular Tachycardia • Catecholaminergic Polymorphic Ventricular Tachycardia • CPVT • Brugada syndrome • Long QT • Short QT
  • CPT Code(s):
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Background:

The inherited arrhythmias comprise a group of genetically heterogeneous diseases Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), Long QT Syndrome, and Short QT Syndrome.  These disorders have an impact across all age groups.  This next-generation sequencing panel is a comprehensive test which targets the coding region of 23 genes associated with arrhythmia.

Reasons for Referral:

  • Presence of arrhythmia.
  • Positive family history for arrhythmia (targeted testing is available if familial mutation is known).
  • Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated. 


Comprehensive Arrhythmias (23 genes):
AKAP9, ANK2, CACNA1C, CACNB2, CALM1, CASQ2, CAV3, GPD1L, HCN4, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SNTA1, TRDN, TRPM4

Methodology:


Specimen Requirements:

Test Performed (Days):

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References:

  1. GeneReviews: Alders et al., 2015, http://www.ncbi.nlm.nih.gov/books/NBK1129/
  2. Genetics Home Reference:  http://ghr.nlm.nih.gov/glossary=longqtsyndrome

Additional Info:

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